Basic Information
| LncRNA/CircRNA Name | F11-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:186286094-186500997 |
| Ensemble | ENSG00000251165 |
| Refseq | NR_033901 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | LIHC tissues and normal tissues, ,hepatocellular carcinoma cell lines (HepG2, Hep3B, Huh-6, and SMMC7721) ,normal liver cell line LO2 |
| Expression Pattern | down-regulated |
| Function Description | F11-AS1 is underexpressed in LIHC and suppresses LIHC progression in return.F11-AS1 can bind with and negatively regulate miR-3146, while miR-3146 can bind with and negatively regulate PTEN.Moreover, F11-AS1 positively regulates the messenger RNA and protein level of PTEN.F11-AS1 mediates PTEN expression by acting as competing endogenous RNA of miR-3146. |
| Pubmed ID | 31168823 |
| Year | 2019 |
| Title | LncRNA F11-AS1 Suppresses Liver Hepatocellular Carcinoma Progression by Competitively Binding With miR-3146 to Regulate PTEN Expression |
External Links
| Links for F11-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |