Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740 |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | ovarian cancer tissues, cell lines (SKOV3, OV90, TOV112D and ES2) |
| Expression Pattern | up-regulated |
| Function Description | AFAP1-AS1 was highly expressed both in ovarian cancer samples and cell lines compared with their corresponding normal counterparts. High AFAP1-AS1 expression was significantly associated with response and FIGO stage. Gain-of-function and loss-of-function experiments showed that AFAP1-AS1 promoted ovarian cancer cells proliferation. Flow cytometry assay showed that knockdown of AFAP1-AS1 promoted ovarian cancer cells apoptosis. |
| Pubmed ID | 28051261 |
| Year | 2016 |
| Title | Expression and functional role of long non-coding RNA AFAP1-AS1 in ovarian cancer. |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |