Basic Information
| LncRNA/CircRNA Name | FAL1 |
| Synonyms | FALEC, FAL1, LINC00568, ncRNA-a1 |
| Region | GRCh38_1:150515757-150518032 |
| Ensemble | ENSG00000228126 |
| Refseq | NR_051960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot |
| Sample | HOKs, SCC6, SCC9, SCC25, HN4, and HN6, OSCC tissues and adjacent normal oral tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA FAL1 was highly expressed in OSCC tissues and cell lines. The proliferative capacity of OSCC cells was significantly inhibited by lncRNA FAL1 knockdown. The mRNA expression of microRNA-761 was lowly expressed in OSCC tissues and cell lines. Dual-Luciferase reporter gene assay showed that lncRNA FAL1 directly bound to microRNA-761. Meanwhile, microRNA-761 expression was negatively regulated by FAL1. CRKL was verified as the target gene of microRNA-761. Both the mRNA and protein levels of CRKL were remarkably upregulated in OSCC tissues and cell lines. CRKL expression was found to be negatively regulated by microRNA-761 in OSCC cells. Lowly expressed microRNA-761 reversed the inhibitory effect of lncRNA FAL1 knockdown on the proliferative potential of OSCC cells. In addition, the overexpression of CRKL reversed the inhibitory effect of lncRNA FAL1 down-regulation on the proliferative potential of OSCC cells as well. |
| Pubmed ID | 31298329 |
| Year | 2019 |
| Title | LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway |
External Links
| Links for FAL1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |