Basic Information
| LncRNA/CircRNA Name | FAL1 |
| Synonyms | FALEC, FAL1, LINC00568, ncRNA-a1 |
| Region | GRCh38_1:150515757-150518032 |
| Ensemble | ENSG00000228126 |
| Refseq | NR_051960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, RNA pull-down assay etc. |
| Sample | cell lines (BT20, HCC1428, HCC202, MCF7, MALME-3M etc.) |
| Expression Pattern | up-regulated |
| Function Description | We identified an oncogene, FAL1, we measured the copy number of FAL1 in 99 cancer cell lines using qPCR and observed FAL1 copy-number gain in 46% of the cell lines. We then extracted the FAL1 RNA expression data from the aforementioned custom RNA array containing 40 cancer cell lines and found a significant and positive correlation between the genomic copy-number and RNA expression of FAL1. FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. The oncogenic activity of FAL1 is partially attributable to its repression of p21. FAL1-specific siRNAs significantly inhibit tumor growth in vivo. |
| Pubmed ID | 25203321 |
| Year | 2014 |
| Title | A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p24 expression in cancer. |
External Links
| Links for FAL1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |