Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740 |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | RNA-seq, qPCR, Western blot etc. |
| Sample | cell line (A549) |
| Expression Pattern | up-regulated |
| Function Description | AFAP1-AS1 was the most significantly upregulated in lung cancer and associated with poor prognosis. AFAP1-AS1 knockdown significantly inhibited the cell invasive and migration capability in lung cancer cells. AFAP1-AS1 knockdown also increased the expression of its antisense protein coding gene, actin filament associated protein 1 (AFAP1), and affected the expression levels of several small GTPase family members and molecules in the actin cytokeratin signaling pathway, which suggested that AFAP1-AS1 promoted cancer cell metastasis via regulation of actin filament integrity. |
| Pubmed ID | 26245991 |
| Year | 2015 |
| Title | AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis. |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |