Basic Information
| LncRNA/CircRNA Name | FAL1 |
| Synonyms | FALEC, FAL1, LINC00568, ncRNA-a1 |
| Region | GRCh38_1:150515757-150518032 |
| Ensemble | ENSG00000228126 |
| Refseq | NR_051960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (LO2, SMMC-7721, Huh7, HepG2, HepG2.2.15), HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA FAL1 was up-regulated in HCC tissues and functioned as an oncogene in HCC.LncRNA FAL1 could accelerate cell proliferation and metastasis as a ceRNA mechanism by competitively binding to miR-1236. Moreover,lncRNA FAL1 was also up-regulated in serum exosome of HCC patients and could transfer lncRNA FAL1 to HCC cells to increase their abilities of cell proliferation and migratio. |
| Pubmed ID | 29421439 |
| Year | 2018 |
| Title | LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells. |
External Links
| Links for FAL1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |