Basic Information
| LncRNA/CircRNA Name | FALEC |
| Synonyms | NA |
| Region | GRCh38_1:150515757-150518032 |
| Ensemble | ENSG00000228126 |
| Refseq | NR_051960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | GC tissues and adjacent normal tissues ,human GC cell lines(SGC-7901, BGC-823, AGS, MKN-45, MGC-803, HGC-27) and the immortalized human gastric epithelial mucosa cell line GES-1 |
| Expression Pattern | up-regulated |
| Function Description | FALEC was upregulated and significantly correlated with lymph node metastasis, TNM stage in gastric cancer (GC).FALEC knockdown significantly inhibited GC cells migration and invasion in vitro. |
| Pubmed ID | 30984243 |
| Year | 2019 |
| Title | Downregulation of Long Non-coding RNA?FALEC?Inhibits Gastric Cancer Cell Migration and Invasion Through Impairing?ECM1?Expression by Exerting Its Enhancer-Like Function |
External Links
| Links for FALEC | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |