Basic Information
| LncRNA/CircRNA Name | FALEC |
| Synonyms | NA |
| Region | GRCh38_1:150515757-150518032 |
| Ensemble | ENSG00000228126 |
| Refseq | NR_051960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Tongue squamous cell carcinoma |
| ICD-0-3 | C02 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | Human TSCC cell lines (SCC-9, CAL-27, SCC-25, SCC-4, SCC-6, SCC-15), TSCC (TC) tissues and normal adjacent tissues |
| Expression Pattern | down-regulated |
| Function Description | The focally amplified long non-coding RNA in epithelial cancer (FALEC) was found downregulated in the tissues of tongue squamous cell carcinoma (TSCC) and was predicted to present a good prognosis by bioinformatics analysis. Experiments indicated that FALEC knockdown significantly increased the proliferation and migration of TSCC cells both in vitro and in vivo; however, FALEC overexpression repressed these malignant behaviors. RNA pull-down and RNA immunoprecipitation demonstrated that FALEC could recruit enhancer of zeste homolog 2 (EZH2) at the promoter regions of extracellular matrix protein 1 (ECM1), epigenetically repressing ECM1 expression. |
| Pubmed ID | 31335317 |
| Year | 2019 |
| Title | Long noncoding RNA FALEC inhibits proliferation and metastasis of tongue squamous cell carcinoma by epigenetically silencing ECM1 through EZH2 |
External Links
| Links for FALEC | GenBank HGNC NONCODE |
| Links for Tongue squamous cell carcinoma | OMIM COSMIC |