Basic Information
| LncRNA/CircRNA Name | FAM83A-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:123201172-123202743 |
| Ensemble | ENSG00000204949 |
| Refseq | NR_024479 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, RIP, Western blot |
| Sample | HCC and adjacent non-tumor tissues,HCC cell lines (SMMC-7721, HepG2, HuH-7, H-97) and human normal liver cell line (LO2) |
| Expression Pattern | up-regulated |
| Function Description | the abundantly increased expression level of FAM83A-AS1 in HCC tissues and cells. FAM83A-AS1 inhibition hampered cell proliferation, migration and elevated cell apoptosis in HCC. Moreover, FAM83A-AS1 could positively regulate FAM83A, and FAM83A could also promote the progression of HCC. In addition, FAM83A-AS1 and FAM83A were both verified to bind with NOP58, and FAM83A-AS1 enhanced the mRNA stability of FAM83A by binding with NOP58. |
| Pubmed ID | 31696213 |
| Year | 2019 |
| Title | Long Noncoding RNA FAM83A-AS1 Facilitates Hepatocellular Carcinoma Progression by Binding With NOP58 to Enhance the mRNA Stability of FAM83A |
External Links
| Links for FAM83A-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |