Basic Information
| LncRNA/CircRNA Name | FAM83A-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:123201172-123202743 |
| Ensemble | ENSG00000204949 |
| Refseq | NR_024479 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, etc. |
| Sample | LUAD tissues and LUSC tissues, human alveolar adenocarcinoma cell line A549 |
| Expression Pattern | up-regulated |
| Function Description | One NAT, family with sequence similarity 83 member A antisense RNA 1 (FAM83A AS1), was found to be markedly upregulated and positively correlated with its cognate sense counterpart, FAM83A, in NSCLC. Moreover, overexpression of FAM83AAS1 increased FAM38A protein levels and induced ERK1/2 phosphorylation downstream of FAM83A in cells. Finally, overexpression of FAM83A AS1 promoted LUAD cell proliferation and invasion. In summary, lncRNA FAM83A AS1 promotes LUAD by increasing FAM83A expression |
| Pubmed ID | 30659636 |
| Year | 2019 |
| Title | Long noncoding antisense RNA FAM83A-AS1 promotes lung cancer cell progression by increasing FAM83A |
External Links
| Links for FAM83A-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |