Basic Information
| LncRNA/CircRNA Name | FAS-AS1 |
| Synonyms | FAS-AS1, FAS-AS, FASAS, SAF |
| Region | GRCh38_1:29554-31109 |
| Ensemble | NA |
| Refseq | NR_028371 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | B-cell lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP, ChIP, ELISA etc. |
| Sample | blood, cell lines (B-lymphocytes, Granta-519) |
| Expression Pattern | down-regulated |
| Function Description | We found that the alternative splicing of Fas in lymphomas is tightly regulated by a long-noncoding RNA corresponding to an antisense transcript of Fas (FAS-AS1). Levels of FAS-AS1 correlate inversely with production of sFas, and FAS-AS1 binding to the RBM5 inhibits RBM5-mediated exon 6 skipping. EZH2, often mutated or overexpressed in lymphomas, hyper-methylates the FAS-AS1 promoter and represses the FAS-AS1 expression. EZH2-mediated repression of FAS-AS1 promoter can be released by DZNeP (3-Deazaneplanocin A) or overcome by ectopic expression of FAS-AS1, both of which increase levels of FAS-AS1 and correspondingly decrease expression of sFas. |
| Pubmed ID | 24811343 |
| Year | 2014 |
| Title | FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma. |
External Links
| Links for FAS-AS1 | GenBank HGNC NONCODE |
| Links for B-cell lymphoma | OMIM COSMIC |