Basic Information
| LncRNA/CircRNA Name | FBXL19-AS1 |
| Synonyms | F-box and leucine-rich repeat protein 19 antisense RNA 1 |
| Region | GRCh38_16:30919319-30923269 |
| Ensemble | ENSG00000260852 |
| Refseq | NR_024348 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Luciferase reporter assay, RIP |
| Sample | Non-carcinogenic epithelial cells (MCF-10A) and breast cancer cells (MCF-7, BT-549, MDA-MB-231, and SKBR3) |
| Expression Pattern | up-regulated |
| Function Description | FBXL19-AS1 was expressed at a high level in breast cancer cells. Loss-of-function experiments revealed that silencing FBXL19-AS1 could impair cell proliferation and induce cell apoptosis in breast cancer.FBXL19-AS1 regulated the expression of Forkhead box M1 (FOXM1) by directly absorbing miR-876-5p. |
| Pubmed ID | 31696201 |
| Year | 2019 |
| Title | FBXL19-AS1 Promotes Cell Proliferation and Inhibits Cell Apoptosis via miR-876-5p/FOXM1 Axis in Breast Cancer |
External Links
| Links for FBXL19-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |