Basic Information
| LncRNA/CircRNA Name | FBXL19-AS1 |
| Synonyms | NA |
| Region | GRCh38_16:30919319-30923269 |
| Ensemble | ENSG00000260852 |
| Refseq | NR_024348 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | lung adenocarcinoma and matched normal adjacent tissues ,human LUAD cells, NCI-H1975 and SPC, |
| Expression Pattern | up-regulated |
| Function Description | FBXL19-AS1 was significantly upregulated in LUAD tissues and high FBXL19-AS1 expression in LUAD was associated with a poor prognosis.FBXL19-AS1 knockdown could arrest LUAD cells in G0/G1 phase and inhibit cell proliferation, migration and invasion in vitro and inhibited LUAD tumor progress in vivo. FBXL19-AS1 could act as a miR-203a-3p sponge. In addition,downregulation of miR-203a-3p reversed growth inhibition of LUAD cells caused by FBXL19-AS1 knockdown.FBXL19-AS1/miR-203a-3p axis was found to associate with baculoviral IAP repeat-containing protein 5.1-A-like (survivin), distal-less homeobox 5, E2F transcription factor 1, and zinc finger E-box binding homeobox 2 to regulate metastasis in LUAD cells. |
| Pubmed ID | 31566718 |
| Year | 2019 |
| Title | Long Noncoding RNA FBXL19-AS1 Induces Tumor Growth and Metastasis by Sponging miR-203a-3p in Lung Adenocarcinoma |
External Links
| Links for FBXL19-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |