Basic Information
| LncRNA/CircRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 |
| Ensemble | ENSG00000088340 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | human osteosarcoma cell lines (MG63, U-2 OS, SaOS-2) ,normal human osteoblastic cell lines (Hfob1.19) |
| Expression Pattern | down-regulated |
| Function Description | FER1L4 was observed to be lowly expressed in osteosarcoma cell lines, especially MG63 cells. Besides, overexpression of FER1L4 remarkably repressed the proliferation, migration and invasion of MG63 cells.FER1L4-induced apoptotic cell death leaded to the activation of caspase-3 and Bax/Bcl2.EMT was tremendously suppressed by increased FER1L4, evidences were the increased E-cadherin and reduced vimentin and fibronectin.FER1L4 could effectively decrease cell stemness in osteosarcoma.Furthermore, the protein levels of p-AKT and p-PI3K were remarkably suppressed when FER1L4 was knocked down. |
| Pubmed ID | 31000382 |
| Year | 2019 |
| Title | Overexpression of FER1L4 Promotes the Apoptosis and Suppresses Epithelial-Mesenchymal Transition and Stemness Markers via Activating PI3K/AKT Signaling Pathway in Osteosarcoma Cells |
External Links
| Links for FER1L4 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |