Basic Information
| LncRNA/CircRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 |
| Ensemble | ENSG00000088340 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | gastric cancer tissues, cell lines (GES-1, AGS, MGC-803, SGC-7901 etc.) |
| Expression Pattern | differential expression |
| Function Description | RB1 is one of miR-106a-5p's targets, and has been validated by dual luciferase reporter assay25. In this study, the interaction between FER1L4 and miR-106a-5p was first predicted by miRcode. Then dual luciferase reporter assay showed that the luciferase activity of the mutant FER1L4 plasmid was about 56% higher than that of the wild-type plasmid. This indicated that the mutations introduced in the seed matches impair the ability of miR-106a-5p to bind to FER1L4. qRT-PCR analysis revealed that transfection of small interfering RNA (siRNA) against FER1L4 not only reduced FER1L4 levels in GES-1, AGS, MGC-803 and SGC-7901, but also reduced RB1 levels in all cells tested. |
| Pubmed ID | 25124853 |
| Year | 2014 |
| Title | Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. |
External Links
| Links for FER1L4 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |