Basic Information
| LncRNA/CircRNA Name | FEZF1-AS1 |
| Synonyms | NR_036484 |
| Region | GRCh38_7:122303658-122310077 |
| Ensemble | ENSG00000230316 |
| Refseq | NR_036484 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | ESCC tissues ,adjacent normal tissues ,ESCC cell lines (EC9706, EC1) , human esophageal epithelial cell line (HET-1A) |
| Expression Pattern | up-regulated |
| Function Description | FEZF1-AS1 was remarkably upregulated in ESCC tissues and cell lines. Silencing of FEZF1-AS1 significantly inhibited the migration and invasion of ESCC cells, while overexpression of FEZF1-AS1 notably accelerated ESCC migration and invasion.We also found that ?-catenin was upregulated in ESCC tissues, and the level of it was positively correlated with the expression of FEZF1-AS1. |
| Pubmed ID | 31191005 |
| Year | 2019 |
| Title | Long Noncoding RNA FEZF1-AS1 Promotes the Motility of Esophageal Squamous Cell Carcinoma Through Wnt/?-catenin Pathway |
External Links
| Links for FEZF1-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |