Basic Information
| LncRNA/CircRNA Name | FEZF1-AS1 |
| Synonyms | NR_036484 |
| Region | GRCh38_7:122303658-122310077 |
| Ensemble | ENSG00000230316 |
| Refseq | NR_036484 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | OS cell lines (U2OS, SAOS2, SW1353, and MG63), fetal osteoblastic cell line hFOB |
| Expression Pattern | up-regulated |
| Function Description | FEZF1-AS1 sponged miR-4443 to promote NUPR1 expression in U2OS and MG63 cells.Furthermore,knockdown of miR-4443 abrogated FEZF1-AS1 silence-induced inhibition of cell proliferation,migration and invasion in osteosarcoma.Finally,we found that restoration of NUPR1 rescued the proliferation,migration and invasion abilities of FEZF1-AS1-depleted U2OS and MG63 cells. In collection,FEZF1-AS1 could promote osteosarcoma progression by sponging miR-4443 to promote NUPR1 expression.The FEZF1-AS1/miR-4443/NUPR1 axis may act as a novel therapeutic strategy for osteosarcoma treatment. |
| Pubmed ID | 29510778 |
| Year | 2018 |
| Title | Long non-coding RNA FEZF1-AS1 promotes osteosarcoma progression by regulating miR-4443/NUPR1 axis. |
External Links
| Links for FEZF1-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |