Basic Information
| LncRNA/CircRNA Name | FEZF1-AS1 |
| Synonyms | NR_036484 |
| Region | GRCh38_7:122303658-122310077 |
| Ensemble | ENSG00000230316 |
| Refseq | NR_036484 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western bolt, RIP, ChIP etc. |
| Sample | LAD tissues, cell lines (SPCA-1, NCI-H1299, A549, NCI-H441, LTEP-a2) |
| Expression Pattern | up-regulated |
| Function Description | FEZF1-AS1 was increased in lung adenocarcinoma tissues and cell lines and high level of FEZF1-AS1 was associated with poor prognosis of lung adenocarcinoma.Besides,we also uncovered that FEZF1-AS1 could suppress p57 expression through recruiting EZH2 and LSD1 to the promoter of p57, thus influenced the cell cycle and proliferation.we determined the expression level of FEZF1-AS1 in LAD cells and found that FEZF1-AS1 was mainly located in nucleus, indicating that FEZF1-AS1 regulated target gene probably at transcriptional level. |
| Pubmed ID | 29262540 |
| Year | 2017 |
| Title | LincRNA FEZF1-AS1 contributes to the proliferation of LAD cells by silencing p57 expression |
External Links
| Links for FEZF1-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |