Basic Information
| LncRNA/CircRNA Name | FGF14-AS2 |
| Synonyms | NA |
| Region | GRCh38_13:102394630-102395703 |
| Ensemble | ENSG00000272143 |
| Refseq | NR_036487 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay, etc. |
| Sample | breast cancer tissues, Breast cancer cells lines (MDA-MB-231 and SK-BR-3) and human epithelial breast cells (MCF-10A) |
| Expression Pattern | down-regulated |
| Function Description | FGF14-AS2 was down-regulated while miR-205-5p was up-regulated in breast cancer tissues and cells and correlated with tumor stage and size. Functionally, the overexpression of FGF14-AS2 or miR-205-5p knockdown suppressed proliferation, migration, and invasion, and induced apoptosis of breast cancer cells. Moreover, FGF14-AS2 could directly bind to miR-205-5p, and the overexpression of FGF14-AS2 undermined the miR-205-5p induced effects on proliferation, migration, invasion, and apoptosis in breast cancer cells. CONCLUSIONS: FGF14-AS2 directly bind to miR-205-5p to repress proliferation, migration, invasion, and induce apoptosis in breast cancer. This study may provide a potential therapeutic strategy for breast cancer. |
| Pubmed ID | 31486497 |
| Year | 2019 |
| Title | Long non-coding RNA FGF14-AS2 represses proliferation, migration, invasion, and induces apoptosis in breast cancer by sponging miR-205-5p |
External Links
| Links for FGF14-AS2 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |