Basic Information
| LncRNA/CircRNA Name | FLVCR1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:212852108-212858088 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, other |
| Sample | serums, OSC tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | Knockdown FLVCR1-AS1 decreased cell growth, migration, invasion, and EMT, as well as increased apoptosis in OSC cells, whereas, overexpression of FLVCR1-AS1 increased cell proliferation, migration, invasion, and EMT, and decreased apoptosis of OSC cells. Besides, FLVCR1-AS1 directly bound to miR-513 and downregulated its expression. Moreover, FLVCR1-AS1 reversed the effect of miR-513 on the OSC cell growth, which might be associated with the role of YAP1. Furthermore, in terms of mechanism, FLVCR1-AS1 promoted EMT in OSC cells. Finally, mice models further confirmed that knockdown FLVCR1-AS1 distinctly suppressed cell growth and EMT in vivo. |
| Pubmed ID | 31412903 |
| Year | 2019 |
| Title | LncRNA FLVCR1-AS1 Mediates miR-513/YAP1 Signaling to Promote Cell Progression, Migration, Invasion and EMT Process in Ovarian Cancer |
External Links
| Links for FLVCR1-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |