Basic Information
| LncRNA/CircRNA Name | FLVCR1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:212852108-212858088 |
| Ensemble | ENSG00000198468 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, in vitro knockdown, Luciferase reporter assay etc. |
| Sample | cell line (LO2, Hep3B, HepG2, Huh7, and PLC/PRF-5), HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA FLVCR1-AS1 was extremely up-regulated in HCC tissues and cell lines. FLVCR1-AS1 expression level was positively correlated with tumor severity.FLVCR1-AS1 knockdown remarkably inhibited HCC cell proliferation,migration,and invasion in vitro and in vivo while induced cell apoptosis. In mechanism, FLVCR1-AS1 acted as a competitive endogenous RNAs to sponge miR-513c which targeted the mRNA of MET for degradation. By directly sponging miR-513c, FLVCR1-AS1 increased MET expression in HCC, and then promoted HCC progression. FLVCR1-AS1 played a positive role in HCC development and progression according to the study in its mechanism,function and clinical manifestation, so that it could be expected to become a new target in HCC prevention and treatment. |
| Pubmed ID | 29574975 |
| Year | 2018 |
| Title | LncRNA FLVCR1-AS1 acts as miR-513c sponge to modulate cancer cell proliferation, migration, and invasion in hepatocellular carcinoma. |
External Links
| Links for FLVCR1-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |