Basic Information
| LncRNA/CircRNA Name | FOXD2-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:47432133-47434641 |
| Ensemble | ENSG00000237424 |
| Refseq | NR_026878 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | temozolomide (TMZ) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | glioma tumor tissues,cell lines (U87, U251, LN229, A172) |
| Expression Pattern | up-regulated |
| Function Description | Highly expressed FOXD2-AS1 was found in glioma. There was more powerful chemotherapeutic resistance of TMZ resistant cell lines than that of the parent cell lines. Silence of FOXD2-AS1 suppressed proliferation and drug resistance and promoted apoptosis of drug-resistant glioma cells. Overexpressed FOXD2-AS1 presented an opposite trend. FOXD2-AS1 could be used as a competing endogenous RNA to adsorb miR-98-5p, thereby up-regulating CPEB4. |
| Pubmed ID | 31770107 |
| Year | 2019 |
| Title | Silencing lncRNA FOXD2-AS1 Inhibits Proliferation, Migration, Invasion and Drug Resistance of Drug-Resistant Glioma Cells and Promotes Their Apoptosis via microRNA-98-5p/CPEB4 Axis |
External Links
| Links for FOXD2-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |