Basic Information
| LncRNA/CircRNA Name | FOXD2-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:47432133-47434641 |
| Ensemble | ENSG00000237424 |
| Refseq | NR_026878 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | OS tissues and adjacent tissues ,OS cell line SOSP-9607 , cell lines(hFOB1.19, U2OS, MG63 and SAOS2) |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of FOXD2-AS1 were significantly upregulated in OS tissues and cells, compared with in adjacent tissues and normal cells.Notably, the overall survival of patients with relatively high FOXD2-AS1 expression in OS tissues was significantly lower than that of patients with relatively low expression.Knockdown of FOXD2-AS1 inhibited the proliferation, migration and invasion of OS cells. The expression levels of ribonucleotide reductase regulatory subunit M2 and phosphoglycerate dehydrogenase were decreased ,following FOXD2-AS1 knockdown.Finally, when FOXD2-AS1 expression was downregulated, tumor growth was significantly reduced and pulmonary metastatic nodules were markedly reduced. |
| Pubmed ID | 31115575 |
| Year | 2019 |
| Title | Downregulation of the Long Non-coding RNA FOXD2-AS1 Inhibits Cell Proliferation, Migration and Invasion in Osteosarcoma |
External Links
| Links for FOXD2-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |