Basic Information
LncRNA/CircRNA Name | FOXD2-AS1 |
Synonyms | NA |
Region | GRCh38_1:47432133-47434641 |
Ensemble | ENSG00000237424 |
Refseq | NR_026878 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | autophagy | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | thyroid cancer |
ICD-0-3 | C73.9 |
Methods | qRT-PCR , Western blot , RIP etc. |
Sample | thyroid cancer tissues and the adjacent normal tissues ,normal primary thyroid follicular epithelial cells (PTFE) and thyroid duct cell carcinoma cells TT ,Thyroid cancer cell lines(PTC cell lines (B-CPAP and BHT101),anaplastic thyroid cancer (ATC) cell lines (CAL-62 and 8305C)) |
Expression Pattern | up-regulated |
Function Description | FOXD2-AS1 was upregulated in thyroid carcinoma tissues and cells. High expression of FOXD2-AS1 significantly correlated with clinical stage, recurrence of thyroid carcinoma.Silencing FOXD2-AS1 inhibited cancer stem cell-like phenotypes and attenuates the anoikis resistance in vitro.Downregulating FOXD2-AS1 represses the tumorigenesis of thyroid carcinoma cells in vivo.FOXD2-AS1 acts as a competitive endogenous RNA (ceRNA) for miR-7-5p, up-regulating the expression of telomerase reverse transcriptase (TERT), which further promotes the cancer stem cells features and anoikis resistance in thyroid cancer cells. |
Pubmed ID | 31024447 |
Year | 2019 |
Title | LncRNA FOXD2-AS1 Functions as a Competing Endogenous RNA to Regulate TERT Expression by Sponging miR-7-5p in Thyroid Cancer |
External Links
Links for FOXD2-AS1 | GenBank HGNC NONCODE |
Links for thyroid cancer | OMIM COSMIC |