Basic Information
| LncRNA/CircRNA Name | FOXD2-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:47432133-47434641 |
| Ensemble | ENSG00000237424 |
| Refseq | NR_026878 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | Normal osteoblastic cell line (hFOB) and osteosarcoma cell lines (MG63, Saos-2, 143B, U2-OS), The osteosarcoma tissues and their corresponding adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | the level of FOXD2-AS1 was significantly up-regulated in the OS tissue and cell lines compared to corresponding controls. The aberrant high-expression of FOXD2-AS1 indicated the poor clinical prognosis of OS patients. Transcription factor HIF-1? could bind with the promoter region of FOXD2-AS1 to activate the transcription in OS cells. Functionally, the knockdown of FOXD2-AS1 could repress the malignant biological properties of OS cells in vitro and vivo, including proliferation, invasion, apoptosis and tumor growth. Mechanistically, FOXD2- AS1 inhibited the expression of p21 via interacting with EZH2 to silence p21 gene expression. |
| Pubmed ID | 31228799 |
| Year | 2019 |
| Title | HIF-1? induced long noncoding RNA FOXD2-AS1 promotes the osteosarcoma through repressing p21 |
External Links
| Links for FOXD2-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |