Basic Information
| LncRNA/CircRNA Name | FOXD3-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:63320884-63324441 |
| Ensemble | ENSG00000230798 |
| Refseq | NR_121634 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP, Luciferase reporter assay etc |
| Sample | skin cutaneous melanoma tissues and contiguous noncancer tissues,cell lines (A2058, SK-MEL-28,SK-MEL-2, A375, HEMa-LP) |
| Expression Pattern | up-regulated |
| Function Description | FOXD3-AS1 was markedly upregulated in melanoma cells. It was validated by loss-of-function assays that cell proliferation and migration were inhibited by FOXD3-AS1 deficiency, while cell apoptosis was facilitated by FOXD3-AS1 knockdown in melanoma. Mechanistic exploration testified that miR-127-3p could bind to FOXD3-AS1 and its expression was negatively modulated by FOXD3-AS1 in melanoma. |
| Pubmed ID | 32354225 |
| Year | 2020 |
| Title | FOXD3-AS1 Contributes to the Progression of Melanoma Via miR-127-3p/FJX1 Axis. |
External Links
| Links for FOXD3-AS1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |