Basic Information
| LncRNA/CircRNA Name | FOXD3-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:63320884-63324441 |
| Ensemble | ENSG00000230798 |
| Refseq | NR_121634 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR etc. |
| Sample | breast cancer tumour and the normal tissues ,breast cancer cell line MDA-MB-231 and BT-549 cells |
| Expression Pattern | up-regulated |
| Function Description | FOXD3-AS1 has significantly high expression in breast cancer tumour comparing with the normal tissue. And patients with low FOXD3-AS1 expression had greater survival probability, smaller tumour size, and less distant metastasis.Silenced FOXD3-AS1 impaired cell proliferation and inhibited cell migration and invasion in breast cancer cell lines. |
| Pubmed ID | 31017311 |
| Year | 2019 |
| Title | lncRNA FOXD3-AS1 Is Associated With Clinical Progression and Regulates Cell Migration and Invasion in Breast Cancer |
External Links
| Links for FOXD3-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |