Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740 |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, etc. |
| Sample | The normal human mammary epithelial cell line (MCF-10A). 4 breast cancer cell lines (MCF-7,SK-RB-3,MDA-MB231,MDA-MB-468). A total of 160 paired breast cancer tissue,adjacent normal tissue. |
| Expression Pattern | up-regulated |
| Function Description | Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis in breast cancer patients and regulated the breast cancer cells proliferation, apoptosis and metastasis. AFAP1-AS1 knockdown can inhibit the proliferation,metastasis and promote apoptosis of MCF-7. However,the AFAP1 expression and actin filament integrity was not affected after AFAP1-AS1 knockdown.The Kaplan-Meier method was used to estimate survival curves,the log-rank test wasused to compare between groups. |
| Pubmed ID | 29974352 |
| Year | 2018 |
| Title | Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis and promotes carcinogenesis of breast cancer. |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |