Basic Information
| LncRNA/CircRNA Name | FOXP4-AS1 |
| Synonyms | NA |
| Region | GRCh38_6:41494853-41548621 |
| Ensemble | ENSG00000234753 |
| Refseq | NR_126415 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot |
| Sample | ESCC cell lines |
| Expression Pattern | up-regulated |
| Function Description | knockdown of FOXP4-AS1 or FOXP4 efficiently suppressed cell proliferation and induced cell apoptosis.Moreover, FOXP4-AS1 positively regulated FOXP4 by interacting with insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to stabilize FOXP4 mRNA. FOXP4-AS1 could upregulate the expression of FOXP4 by sponging miR-3184-5p. |
| Pubmed ID | 32159250 |
| Year | 2020 |
| Title | YY1-induced upregulation of FOXP4-AS1 and FOXP4 promote the proliferation of esophageal squamous cell carcinoma cells |
External Links
| Links for FOXP4-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |