Basic Information
| LncRNA/CircRNA Name | FOXP4-AS1 |
| Synonyms | NA |
| Region | GRCh38_6:41494853-41548621 |
| Ensemble | ENSG00000234753 |
| Refseq | NR_126415 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | osteosarcoma tissues, cell lines (HOS, Saos2, MG63, and U2OS) |
| Expression Pattern | up-regulated |
| Function Description | FOXP4-AS1 is overexpressed in OS, and is the independent risk factor in OS prognosis. Upregulated FOXP4-AS1 promotes the proliferation, migration and cell cycle, but inhibits apoptosis of OS cells. Furthermore, FOXP4-AS1 participates in the development and progression of OS by downregulating LATS1 via binding to LSD1 and EZH2. |
| Pubmed ID | 29859193 |
| Year | 2018 |
| Title | FOXP4-AS1 Participates in the Development and Progression of Osteosarcoma by Downregulating LATS1 via Binding to LSD1 and EZH2 |
External Links
| Links for FOXP4-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |