Basic Information
| LncRNA/CircRNA Name | FOXP4-AS1 |
| Synonyms | NA |
| Region | GRCh38_6:41494853-41548621 |
| Ensemble | ENSG00000234753 |
| Refseq | NR_126415 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP |
| Sample | AGS and BGC7901 cells, GC and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | FOXP4-AS1 was upregulated in GC tissues relative to controls. Its level was higher in GC patients with stage III-IV than those with stage I-II. The survival rate was lower in GC patients presenting the high expression of FOXP4-AS1 compared with those presenting low expression. Transfection of sh-FOXP4-AS1 1 or sh-FOXP4-AS1 2 attenuated proliferative, migratory, and invasive abilities of AGS and BGC7901 cells. FOXP4-AS1 could bind to LSD1 and EZH2, and positively regulated their expression levels. Transfection of sh-LSD1 or sh-EZH2 reduced the proliferative ability of GC cells. |
| Pubmed ID | 31646567 |
| Year | 2019 |
| Title | The carcinogenic complex lncRNA FOXP4-AS1/ EZH2/LSD1 accelerates proliferation, migration and invasion of gastric cancer |
External Links
| Links for FOXP4-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |