Basic Information
| LncRNA/CircRNA Name | FOXP4-AS1 |
| Synonyms | FENDRR, FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 |
| Region | GRCh38_16:86474529-86509099 |
| Ensemble | ENSG00000268388 |
| Refseq | NR_033925 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Flow cytometry assay etc. |
| Sample | CRC tissues, cell lines (DLD-1, HT-29, HCT116, SW480 and Lovo) |
| Expression Pattern | up-regulated |
| Function Description | We found that FOXP4-AS1 was up-regulated in CRC tissues and cell lines and that its overexpression positively correlated with advanced pathological stages and larger tumour size. Additionally, we found that FOXP4-AS1 knockdown inhibited cell proliferation and induced apoptosis. Furthermore, FOXP4-AS1 knockdown induced marked increase in number of cells in G0/G1 phase and reduction in number of cells in S phase, in DLD-1, HT-29 and HCT116 cell lines. Consistent with these findings, FOXP4-AS1 silencing inhibited tumour growth in vivo. |
| Pubmed ID | 27790757 |
| Year | 2017 |
| Title | Long non-coding RNA FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer. |
External Links
| Links for FOXP4-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |