Basic Information
| LncRNA/CircRNA Name | FTH1P3 |
| Synonyms | FTH1P3,FTHL3,FTHL1P |
| Region | GRCh38_2:27392784-27393367 |
| Ensemble | ENSG00000213453 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | Western blotting, qRT-PCR |
| Sample | NSCLC tumor tissues,lung epithelial cell line (BEAS-2B), human bronchial epithelial cell line (HBE) and three NSCLC cell lines (A549, H596, and SPCA1) |
| Expression Pattern | up-regulated |
| Function Description | FTH1P3 was highly expressed in NSCLC tumor tissues and NSCLC-derived cell lines, and high expression of FTH1P3 was associated with advanced TNM stage and lymph node metastasis. NSCLC patients with high FTH1P3 expression had a poor overall survival relative to patients with low FTH1P3 expression. Through loss-of-function studies, FTH1P3 inhibition was demonstrated to suppress NSCLC cell migration and invasion in vitro. |
| Pubmed ID | 31933766 |
| Year | 2019 |
| Title | Long Non-Coding RNA FTH1P3 Promotes the Metastasis and Aggressiveness of Non-Small Cell Lung Carcinoma by Inducing Epithelial-Mesenchymal Transition |
External Links
| Links for FTH1P3 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |