Basic Information
| LncRNA/CircRNA Name | FTX |
| Synonyms | NA |
| Region | GRCh38_X:73946555-74293574 |
| Ensemble | ENSG00000230590 |
| Refseq | NR_028379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blotting, Dual luciferase reporter analysis, RIP |
| Sample | OS and adjacent normal tissue,OS cell lines (U20S, MG63, 143B, Saos-2) and one normal cell line (HOS) |
| Expression Pattern | up-regulated |
| Function Description | FTX and TXNRD1 were abnormally upregulated in OS, whereas miR-320a expression was significantly decreased.both FTX and TXNRD1 could combine with miR-320a. A series of functional experiments indicated that knockdown of FTX could suppress OS cell proliferation and migration, while facilitating apoptosis ability simultaneously. |
| Pubmed ID | 31920141 |
| Year | 2020 |
| Title | LncRNA FTX Inhibition Restrains Osteosarcoma Proliferation and Migration via Modulating miR-320a/TXNRD1 |
External Links
| Links for FTX | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |