Basic Information
| LncRNA/CircRNA Name | AFDN-DT |
| Synonyms | NA |
| Region | GRCh38_6:167823876-167826709 |
| Ensemble | ENSG00000198221 |
| Refseq | NR_027906 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-qPCR |
| Sample | gastric cancer cell line |
| Expression Pattern | up-regulated |
| Function Description | AFDN-DT, an lncRNA that is repressed in gastric cancers (GC), functions as a tumour suppressor by inhibiting cell growth and metastasis through transcriptional repression of genes involved in metastasis. |
| Pubmed ID | 31981317 |
| Year | 2019 |
| Title | Tumour suppressive long non-coding RNA AFDN-DT inhibits gastric cancer invasion via transcriptional regulation |
External Links
| Links for AFDN-DT | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |