Basic Information
| LncRNA/CircRNA Name | FUNDC2P4 |
| Synonyms | NA |
| Region | GRCh38_22:39155525-39155945 |
| Ensemble | ENSG00000227009 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qRT-PCR, Western blot |
| Sample | The human HCC tissues, cell lines (Huh7, Hep 3B, SMMC 7721 and HCCLM3) |
| Expression Pattern | down-regulated |
| Function Description | Huh7-H presented characteristic EMT morphological changes. WB analysis showed significantly decreased E-cadherin in Huh7-H cells. Transwell assays indicated the abilities of Huh7-H cells in migration and invasion were evidently strengthened. A new lncRNA, FUNDC2P4, was identified by LncPath human EMT array to be significantly down-regulated in Huh7-H cells. In vitro studies showed overexpression of FUNDC2P4 inhibited proliferation, invasion and migration potential and up-regulated E-cadherin expression in SMMC-7721 cells, whereas silencing FUNDC2P4 promoted these potentials and down-regulated E-cadherin expression in Huh7 cells. |
| Pubmed ID | 29295626 |
| Year | 2018 |
| Title | LncRNA FUNDC2P4 down-regulation promotes epithelial-mesenchymal transition by reducing E-cadherin expression in residual hepatocellular carcinoma after insufficient radiofrequency ablation. |
External Links
| Links for FUNDC2P4 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |