Basic Information
| LncRNA/CircRNA Name | GACAT1 |
| Synonyms | NA |
| Region | GRCh38_2:107754112-107822129 |
| Ensemble | ENSG00000232991 |
| Refseq | NR_126369 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay etc |
| Sample | breast cancer tissue ,cell lines(cell lines MDA-MB-231, BCap-37 and MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | The level of GACAT1 in breast cancer cell lines was further explored. The effects of GACAT1 and microRNA-875-3p on cell proliferation and cycle were detected by cell counting kit-8 (CCK-8) and flow cytometry. The binding relationship between microRNA-875-3p and STON2, microRNA-875-3p and GACAT1 was examined by a dual luciferase reporting assay. It was confirmed by rescue experiments whether GACAT1 canregulate the level of STON2 by binding to microRNA-875-3p. GACAT1 level was clearly enhanced in breast cancer tissues compared to that of the adjacent tissues. |
| Pubmed ID | 32194758 |
| Year | 2020 |
| Title | Long-chain Non-Coding RNA GACAT1 Promotes Development and Progression of Breast Cancer by Targeting microRNA-875-3p |
External Links
| Links for GACAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |