Basic Information
| LncRNA/CircRNA Name | GACAT1 |
| Synonyms | LINC00876 |
| Region | GRCh38_2:107754112-107822129 |
| Ensemble | ENSG00000232991 |
| Refseq | NR_126369 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Luciferase reporter assay, Western blot, other |
| Sample | GC tissues and cell lines (BGC-823, MGC-803, SGC7901 and HGC-27) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of GACAT1 promoted GC cell proliferation, invasion and migration. We also determined that miR-149 directly interacts with the target site on GACAT1. Furthermore, we investigated that miR-149 downregulated ZBTB2 and SP1 expressions which were induced by GACAT1, miR-149 inhibited GC cell growth and invasion mediated by GACAT1. In conclusion, we found that miR-149 downregulated ZBTB2 and SP1 expressions, and inhibited GC cell progression mediated by GACAT1. Therefore, we indicated that GACAT1 and miR-149 may be potential therapeutic targets for GC. |
| Pubmed ID | 30405842 |
| Year | 2018 |
| Title | LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1 |
External Links
| Links for GACAT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |