Basic Information
| LncRNA/CircRNA Name | GACAT3 |
| Synonyms | GACAT3, LINC01458, lncRNA-AC130710 |
| Region | GRCh38_2:16050427-16085801 |
| Ensemble | ENSG00000236289 |
| Refseq | NR_126559 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (FHC, HT29, HCT116,SW480, LoVo, and 293T), CRC tissues |
| Expression Pattern | up-regulated |
| Function Description | GACAT3 was highly expressed in CRC tissues and cell lines. Si-GACAT3 significantly decreased cell proliferation, motility, and invasiveness both in vitro and in vivo. We confirmed that downregulated GACAT3 significantly increased the expression of miR-149, and miR-149 binds to GACAT3 in a sequence-specific manner using luciferase reporter assays and pull-down assay. Further functional experiments indicated that GACAT3 could directly upregulate SP1 and STAT3 expressions by functioning as a competing endogenous RNA for miR-149, and consequentially, promoting CRC cell proliferation and invasion in vitro. |
| Pubmed ID | 29593420 |
| Year | 2018 |
| Title | Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149. |
External Links
| Links for GACAT3 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |