Basic Information
| LncRNA/CircRNA Name | GACAT3 |
| Synonyms | GACAT3, LINC01458, lncRNA-AC130710 |
| Region | GRCh38_2:16050427-16085801 |
| Ensemble | ENSG00000236289 |
| Refseq | NR_126559 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, Dual luciferase reporter assay, Flow cytometry assay etc. |
| Sample | cell lines (HGC-27 and SGC-7901) |
| Expression Pattern | up-regulated |
| Function Description | The siRNA-mediated knockdown of GACAT3 significantly decreased cell proliferation of the gastric cancer HGC-27 cells, in which GACAT3 is overexpressed. Furthermore, GACAT3 overexpression in gastric cancer SGC-7901 cells promoted cell growth. Moreover, GACAT3 expression in HGC-27 cells was greatly upregulated by IL-6 treatment in a concentration-dependent manner. |
| Pubmed ID | 27644247 |
| Year | 2016 |
| Title | Novel long non-coding RNA GACAT3 promotes gastric cancer cell proliferation through the IL-6/STAT3 signaling pathway. |
External Links
| Links for GACAT3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |