Basic Information
| LncRNA/CircRNA Name | GACAT3 |
| Synonyms | GACAT3, LINC01458, lncRNA-AC130710 |
| Region | GRCh38_2:16050427-16085801 |
| Ensemble | ENSG00000236289 |
| Refseq | NR_126559 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase activity assay, etc. |
| Sample | breast cancer tissues, cell lines (MCF-7, MDA-MB-231, MDA-MB-468, MDA-MB-453, T-47D, SK-BR-3, MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | GACAT3 promotes breast cancer malignancy by sponging miR-497, leading to the enhancement of its endogenous target CCND2. |
| Pubmed ID | 29945347 |
| Year | 2018 |
| Title | LncRNA GACAT3 predicts poor prognosis and promotes cell proliferation in breast cancer through regulation of miR-497/CCND2. |
External Links
| Links for GACAT3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |