Basic Information
| LncRNA/CircRNA Name | GAPLINC |
| Synonyms | GAPLINC, LINC01540 |
| Region | GRCh38_18:3466250-3478978 |
| Ensemble | ENSG00000266835 |
| Refseq | NR_110429 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, other |
| Sample | NSCLC tissues and cell lines (H23, H522) |
| Expression Pattern | up-regulated |
| Function Description | In vitro cell experiment showed that over-expression of TGF-?1 significantly up-regulated the expression of GAPLINC, while over-expression of GAPLINC failed to affect TGF-?1. Follow-up study showed that high GAPLINC level in NSCLC tissue was closely correlated with poor survival rate of NSCLC patients. Over-expressions of TGF-?1 and GAPLINC resulted to accelerated migration and invasion of NSCLC cells. In addition, the silencing of GAPLINC siRNA attenuated the effect of TGF-?1 treatment. |
| Pubmed ID | 31447565 |
| Year | 2019 |
| Title | TGF-?1 Mediates lncRNA GAPLINC Expression to Promote the Migration and Invasion of Non-Small Cell Lung Cancer |
External Links
| Links for GAPLINC | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |