Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | osteosarcoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Compared with the controls, patients were found to have significantly lower rate of genotype del/del. The frequency of allele del was significantly lower in the patients than in the controls. Compared with than patients with genotype ins/ins, those with genotype del/del had remarkably higher expression of GAS5. Patients with genotype del/del were found to have obviously hypermethylation at the 7th CpG site as compared with those with genotype ins/ins. The genetic variant rs145204276 is functionally associated with the susceptibility of OS, which can function as a protective factor in the incidence of OS possibly through the regulation of GAS5. |
| Pubmed ID | 30013899 |
| Year | 2018 |
| Title | A Promoter Variant of lncRNA GAS5 Is Functionally Associated With the Development of Osteosarcoma |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |