Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | hepatocellular carcinoma tissues ,adjacent normal tissues ,HCC cell lines(SMMC-7721 ,HepG2 ) |
| Expression Pattern | down-regulated |
| Function Description | GAS5 and miR-1323 could interact with each other and affect biological processes of HCC cells. Furthermore, we identified the negative correlations between miR-1323 and TP53INP1, and between miR-1323 and GAS5 in tumor tissues of patients with HCC.In this study, we found that miR-1323 was up-regulated and lncRNA GAS5 was down-regulated in tumor tissues of patients with HCC.Our results also showed that GAS5 and miR-1323 could interact with each other and affect proliferation and invasion of HCC cells. |
| Pubmed ID | 31190897 |
| Year | 2019 |
| Title | LncRNA GAS5-mediated miR-1323 Promotes Tumor Progression by Targeting TP53INP1 in Hepatocellular Carcinoma |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |