Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | GC and paired adjacent normal epithelial tissues ,Human gastric epithelial cell line RGM-1 cell ,gastric cancer cell lines (HCG-27 and SGC-7901) |
| Expression Pattern | down-regulated |
| Function Description | Herein, the decreased GAS5 and increased miRNA-106a-5p levels were observed in GC and cell lines. GAS5 level was significantly inversely correlated with miRNA-106a-5p level in GC tissues. GAS5 bound to miRNA-106a-5p and negatively regulated its expression in GC cells.GAS5 overexpression suppressed GC cell proliferation, migration and invasion capabilities, and promoted apoptosis, while miRNA-106a-5p overexpression inverted the functional effects induced by GAS5 overexpression.In vivo, GAS5 overexpression inhibited tumor growth by negatively regulating miRNA-106a-5p expression.GAS5 overexpression inactivated the Akt/mTOR pathway by suppressing miRNA-106a-5p expression in vitro and in vivo |
| Pubmed ID | 31182630 |
| Year | 2019 |
| Title | Overexpression of long noncoding RNA GAS5 suppresses tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mTOR pathway |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |