Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR etc. |
| Sample | NSCLC and normal healthy control blood |
| Expression Pattern | down-regulated |
| Function Description | The results showed significant downregulation of GAS5 expression and upregulation of SOX2OT in NSCLC patients compared with controls.Furthermore, the expression level of GAS5 was declined in stage IV of NSCLC, but SOX2OT expression was increased sharply in stages III and IV.The combination of GAS5 and SOX2OT showed differentiation NSCLC patients from controls with increased sensitivity and specificity. |
| Pubmed ID | 31077615 |
| Year | 2019 |
| Title | Circulating Long Non-Coding RNA GAS5 and SOX2OT as Potential Biomarkers for Diagnosis and Prognosis of Non-Small Cell Lung Cancer |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |