Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | NA |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | sorafenib | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | human tumor cell lines derived from hepatocellular (HA22T/VGH, HUH6, HepG2 and SKHep1C3), breast (MCF-7 and HCC 1937) and renal (ACHN, Caki-1 and CRBM 1990) carcinomas, the human HCC tissues ,the corresponding peritumoral (PT) non-tumor tissues, blood |
| Expression Pattern | down-regulated |
| Function Description | sorafenib mediated the dysregulation of the lncRNAs GAS5, HOTTIP and HOXA-AS2 and the miR-126-3p, in a panel of human cancer cell lines (HCC, renal and breast carcinomas). By luciferase gene reporter assay, we discovered that GAS5 may act as a sponge for miR-126-3p in HCC cells. The expression level of GAS5 and miR-126-3p was verifed in human liquid and/or solid biopsies from HCC patients. miR-126-3p expression in HCC tissues was decreased respect to their correspondent peritumoral tissues. The levels of plasmatic circulating miR-126-3p and GAS5 were signifcantly higher and lower in HCC patients compared to healthy subjects, respectively. |
| Pubmed ID | 31235746 |
| Year | 2019 |
| Title | Diferential expression profling of long non-coding RNA GAS5 and miR-126-3p in human cancer cells in response to sorafenib |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |