Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, RNAi |
| Sample | cell lines (ATCC, CCL-2,ATCC, CCL-229) |
| Expression Pattern | up-regulated |
| Function Description | Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases; GAS5 was up-regulated in GC-resistant cells and accumulated more in the cytoplasm compared to the nucleus in response to the drug. GAS5 knockdown reduced the proliferation during GC treatment.GAS5 could be considered a novel pharmacogenomic marker useful for the personalization of GC therapy. |
| Pubmed ID | 28722800 |
| Year | 2017 |
| Title | Role of the Long Non-Coding RNA GAS5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |