Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | cell lines (MG-63 and OS-732, hFOB1.19) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA GAS5 was down-regulated in MG-63 and OS-732 cells compared to hFOB1.19 cells.Silence of lncRNA GAS5 significantly promoted MG-63 cells viability,migration and invasion,and up-regulated Cyclin D1,Cyclin B1,CDK1 and CDK4 expressions.miR-203a was negatively regulated by lncRNA GAS5.The promoting activities of lncRNA GAS5 silence on MG-63 cells growth and metastasis were reversed by miR-203a suppression.lncRNA GAS5 silence,miR-203a overexpression,and TIMP2 silence could activate PI3K/AKT/GSK3B signaling while block NF-kB signaling.LncRNA GAS5 might be a tumor suppressor in osteosarcoma via sponging miR-203a,sequestering miR-203a away from TIMP2. |
| Pubmed ID | 29414815 |
| Year | 2018 |
| Title | LncRNA GAS5 Represses Osteosarcoma Cells Growth and Metastasis via Sponging MiR-203a. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |