Basic Information
| LncRNA/CircRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 |
| Ensemble | ENSG00000234741 |
| Refseq | NR_002578 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase activity |
| Sample | Liver Cancer cell lines ( A549, NCI-H1299, H460, SK-MES-1,H157, H358), Liver Cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Taken together, the data of the present study demonstrated a novel mechanism by which GAS5/miR-21/PTEN affects the sensitivity of NSCLC to DDPbased therapy. potential prognostic marker and therapeutic target.LncRNAs commonly exerts their functions through the interaction with miRNAs |
| Pubmed ID | 28686971 |
| Year | 2017 |
| Title | GAS5 knockdown reduces the chemo-sensitivity of non-small cell lung cancer (NSCLC) cell to cisplatin (DDP) through regulating miR-21/PTEN axis. |
External Links
| Links for GAS5 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |